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The bellow is only a general description of active ingredients and prescribing physicians make the final choice of what is appropriate for each patient.
We can compound topical multi-modal creams incorporating Ketoprofen, Diclofenac, Amitriptyline, Baclofen, Lidocaine, Camphor and Menthol based on a consultation with one of our Pain Management Pharmacists and a healthcare provider. We are available to speak to Doctors to find a unique solution for your pain. Topical cream formulas Generally target both muscle stiffness or spasm and joint pain and inflammation.
Ketoprofen and Diclofenac a COXI and COXII non-steroidal anti-inflammatory drugs are used by sport medicine doctors and orthopaedic surgeons to treat acute and chronic pain and inflammation.
Amitriptyline, already recommended as first line treatment for some kind of pain act on sodium channels. Amitriptyline acts as an inhibitor of voltage gated sodium channels in the peripheral nerves and was found to be a more potent anaesthetic than bupivacaine. Topical agents containing amitriptyline have shown clinical efficacy in pain management.
Baclofen appears to have peripheral analgesic properties. Although a GABAergic agent orally, its topical mechanism of action is related to its potassium channel opening property. Chronic pain is associated with abnormal excitability of the somatosensory system and remains poorly treated in primary practice. Potassium (K+) channels are crucial determinants of neuronal activity throughout the nervous system. Opening of these channels facilitates a hyperpolarizing K+ efflux across the plasma membrane that counteracts inward ion conductance and therefore limits neuronal excitability.
Local analgesic agents such as Lidocaine suppress the activity of peripheral sodium channels within sensory afferents and subsequent pain transmission.
Ketamine, an NMDA receptor antagonist act as a very potent pain killer when used topically in a cream. Some healthcare providers use Ketamine in musculoskeletal conditions.
Doctors are free to contact us to find out if any of the above ingredients are suitable for their patient's pain.
We bill Compounded Creams and Medications directly to insurance. No need to deal with the uncertainty of insurance claims.